당뇨황반부종에서 망막두께분석기로 측정한 망막두께와 다국소망막전위도의 반응의 연관성

Abstract

PURPOSE: To assess the correlation between retinal thickness determined with a retinal thickness analyzer (RTA) and the responses of multifocal electroretinogram (mfERG) in patients with diabetic macular edema. METHODS: RTA and mfERG were performed in patients with diabetic macular edema (20eyes, 10 patients) and normal subjects (10eyes, 10 patients). The measured retina of RTA and mfERG overlapped based on the anatomical landmarks of the fundus. The center of macula was defined as Area 1", and the central 5 degree retina including the center of macula was defined as "Area 2". The correlations between retinal thickness and the local responses in each area were assessed. RESULTS: The mean retinal thickness of patients with diabetic macular edema was significantly greater than that of normal subject, and the results of mfERG typically represented decreased amplitudes and delayed latencies. In the matching of retinal thickness and local responses in Area 2, amplitudes of N1 & P1 decreased and latency of P1 delayed as the retinal thickness increased. The correlation was prominent in patients with diabetic macular edema. CONCLUSIONS: In the matching of RTA and mfERG of patients with diabetic macular edema, retinal thickness and local responses were significantly correlated."