정신분열병의 임상증상과 P300의 관계

Abstract

Objective：This research was performed to evaluate the relation clinical symptoms and P300 in patients with schizophrenia. Methods：25 patients with schizophenia by DSM-Ⅳ in Soonchunhyang Chunan University hospital were participated. Clinical symptoms were checked by BPRS(Brief Psychiatric Rating Scale) and PANSS(Positive and Negative Syndrome Scale). Auditory event related potentials P300 components were obtained with “Oddball paradigm”. Results：P300 in T 3 was smaller and more delayed than T 4 in patients with schizophrenia. Especially, P300 on T 3 were correlated with BPRS scores and negative symptoms scores of PANSS, which were also correlated with P300 on Fz. Conclusion：The results of this study suggest that P300 on frontal and left temporal lobe reflect clinical symptoms in patients with schizophrenia.