http://schca-ir.schmc.ac.kr/handle/2022.oak/171 Thu, 22 Oct 2026 23:35:16 GMT 2026-10-22T23:35:16Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4973 Title: Role of WW domain-containing oxidoreductase in regulating lipid production via AKT signaling in immortalized human sebocytes All Author(s): Min Jeong Shin; Yun Su Eun; Chang Deok Kim; Young Lee; Whiin Lee; Jae Yun Kim; Youngsook Kim; Sul Hee Lee; Jung Eun Kim Wed, 31 Dec 2025 15:00:00 GMT http://schca-ir.schmc.ac.kr/handle/2022.oak/4973 2025-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4949 Title: Multispectral Pulsed Photobiomodulation Enhances Re-Epithelialization via Keratinocyte Activation in Full-Thickness Skin Wounds All Author(s): Joo Hyun Kim; Delgerzul Baatar; Myung Jin Ban; Ji Won Son; Jihye Choi; Chan Hee Gil; Min-Kyu Kim; Sung Sik Hur; Jung Eun Kim; Yongsung Hwang Abstract: Chronic wound healing is a complex and tightly regulated process requiring coordinated epithelial and stromal regeneration. Photobiomodulation (PBM) using low-level red light-emitting diode (LED) therapy has emerged as a non-invasive approach to enhancing skin repair. In this study, we evaluated the therapeutic efficacy of a pulsed, multi-wavelength LED system on full-thickness excisional wound healing in a normal murine model. Daily LED treatment significantly accelerated wound closure, promoted re-epithelialization, and improved dermal architecture. Histological and immunohistochemical analyses revealed enhanced epidermal stratification, reduced inflammation, and improved collagen organization. Molecular profiling demonstrated increased expression of proliferation marker Ki67, keratins CK14 and CK17, and extracellular matrix-related genes including MMPs, Col1a1, and Col3a1. In vitro assays using HaCaT keratinocytes showed accelerated scratch wound closure and cytoskeletal remodeling following PBM exposure. These findings suggest that pulsed PBM promotes coordinated epithelial regeneration and matrix remodeling, highlighting its potential as a tunable and effective therapeutic modality for accelerating cutaneous wound healing under physiological conditions. Tue, 31 Dec 2024 15:00:00 GMT http://schca-ir.schmc.ac.kr/handle/2022.oak/4949 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4907 Title: Multispectral Pulsed Photobiomodulation Enhances Diabetic Wound Healing via Focal Adhesion-Mediated Cell Migration and Extracellular Matrix Remodeling All Author(s): Jihye Choi; Myung Jin Ban; Chan Hee Gil; Sung Sik Hur; Laurensia Danis Anggradita; Min-Kyu Kim; Ji Won Son; Jung Eun Kim; Yongsung Hwang Abstract: Chronic diabetic wounds affect 15-20% of patients and are characterized by impaired healing due to disrupted hemostasis, inflammation, proliferation, and extracellular matrix (ECM) remodeling. Low-level light therapy (LLLT) has emerged as a promising noninvasive strategy for enhancing tissue regeneration. Here, we developed a multispectral pulsed LED system combining red and near-infrared light to stimulate wound healing. In vitro photostimulation of human keratinocytes and fibroblasts on biomimetic hydrogels enhanced adhesion, spreading, migration, and proliferation via increased focal adhesion kinase (pFAK), paxillin, and F-actin expression. In vivo, daily LED treatment of streptozotocin-induced diabetic wounds accelerated closure and improved ECM remodeling. Histological and molecular analyses revealed elevated levels of MMPs, interleukins, collagen, fibronectin, FGF2, and TGF-β1, supporting regenerative healing without excessive fibrosis. These findings demonstrate that multispectral pulsed photobiomodulation enhances diabetic wound healing through focal adhesion-mediated cell migration and ECM remodeling, offering a cost-effective and clinically translatable approach for chronic wound therapy. Tue, 31 Dec 2024 15:00:00 GMT http://schca-ir.schmc.ac.kr/handle/2022.oak/4907 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4859 Title: Primary Cutaneous CD30+ Lymphoproliferative Disorders in South Korea: A Nationwide, Multi-Center, Retrospective, Clinical, and Prognostic Study All Author(s): Woo Jin Lee; Sook Jung Yun; Joon Min Jung; Joo Yeon Ko; Kwang Ho Kim; Dong Hyun Kim; Myung Hwa Kim; You Chan Kim; Jung Eun Kim; Chan-Ho Na; Je-Ho Mun; Jong Bin Park; Ji-Hye Park; Hai-Jin Park; Dong Hoon Shin; Jeonghyun Shin; Sang Ho Oh; Seok-Kweon Yun; Dongyoun Lee; Seok-Jong Lee; Seung Ho Lee; Young Bok Lee; Soyun Cho; Sooyeon Choi; Jae Eun Choi; Mi Woo Lee; Korean Society of Dermatopathology Abstract: Background: Primary cutaneous CD30+ lymphoproliferative disorders (pcCD30-LPDs) are a diseases with various clinical and prognostic characteristics. Objective: Increasing our knowledge of the clinical characteristics of pcCD30-LPDs and identifying potential prognostic variables in an Asian population. Methods: Clinicopathological features and survival data of pcCD30-LPD cases obtained from 22 hospitals in South Korea were examined. Results: A total of 413 cases of pcCD30-LPDs (lymphomatoid papulosis [LYP], n=237; primary cutaneous anaplastic large cell lymphoma [C-ALCL], n=176) were included. Ninety percent of LYP patients and roughly 50% of C-ALCL patients presented with multiple skin lesions. Both LYP and C-ALCL affected the lower limbs most frequently. Multiplicity and advanced T stage of LYP lesions were associated with a chronic course longer than 6 months. Clinical morphology with patch lesions and elevated serum lactate dehydrogenase were significantly associated with LPDs during follow-up in LYP patients. Extracutaneous involvement of C-ALCL occurred in 13.2% of patients. Lesions larger than 5 cm and increased serum lactate dehydrogenase were associated with a poor prognosis in C-ALCL. The survival of patients with C-ALCL was unaffected by the anatomical locations of skin lesions or other pathological factors. Conclusion: The multiplicity or size of skin lesions was associated with a chronic course of LYP and survival among patients with C-ALCL. Tue, 31 Dec 2024 15:00:00 GMT http://schca-ir.schmc.ac.kr/handle/2022.oak/4859 2024-12-31T15:00:00Z