http://schca-ir.schmc.ac.kr/handle/2022.oak/105 Thu, 22 Oct 2026 21:05:23 GMT 2026-10-22T21:05:23Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4919 Title: Clinical Practice Guidelines for the Pre-hospital Stage of Acute Stroke in Korea II : Transport Decisions for Patients with Acute Ischemic Stroke All Author(s): Jae Sang Oh; Yuna Jo; Jong Min Lee; Hong Suk Ahn; Jung-Jae Kim; Kyoung Min Jang; Gi-Yong Yun; Jang Hun Kim; Dongwook Seo; Hyeong Jin Lee; Jinwoo Jeong; Kyoung-Chul Cha; Yong Soo Cho; Su Jin Kim; Jongkyu Park; Won-Sang Cho; Hoon Kim; Young Woo Kim; Seung Hun Sheen; Sang Weon Lee; Jae Whan Lee; Tae Gon Kim; Sung-Kon Ha; Sukh Que Park; oon Chan Kwon Abstract: The mothership (MS) model, where patients are directly transferred to a thrombectomy-capable center, and the drip-and-ship (DS) model, where thrombolysis is initiated at the nearest primary stroke center before transfer for thrombectomy, are the primary transport modes for patients with stroke. We aimed to establish guidelines for selecting the appropriate transfer strategy based on emergent large vessel occlusion (LVO). We developed this guideline based on evidence from systematic reviews and meta-analyses via a de novo process. A systematic literature review was conducted across four databases (MEDLINE, Embase, Cochrane, and KoreaMed) to answer three Population, Intervention, Comparison, and Outcome questions comparing MS and DS models. The risk of bias was assessed using the Newcastle-Ottawa Scale. Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagrams and meta-analyses were generated for functional outcomes, mortality, and successful recanalization. Twenty-six non-randomized controlled studies showed that the MS model improved good functional outcomes by approximately 14% compared with the DS model (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.00-1.30). Fifteen studies reported that mortality in the MS and DS models showed no significant differences (OR, 0.97; 95% CI, 0.84-1.11). Twenty-four studies revealed no significant difference in successful recanalization between the MS and DS models (OR, 0.87; 95% CI, 0.68-1.10). The MS model should be considered first to improve the functional outcome of patients with LVO. However, if thrombectomy cannot be performed immediately after thrombolysis, or if a thrombectomy-enabled hospital is not nearby, the DS model should be considered by stroke specialists depending on transportation time and regional factors. We suggest a mixed approach with the DS model based on specific circumstances or regions to ensure the optimum treatment of patients with acute ischemic stroke (AIS). Appropriate transport for patients with LVO improves the prognosis of AIS. Tue, 31 Dec 2024 15:00:00 GMT http://schca-ir.schmc.ac.kr/handle/2022.oak/4919 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4920 Title: Unveiling blood biomarkers for neuronal hyperplasticity: Insights from AD molecular subtyping, a comprehensive review All Author(s): Niti Sharma; Danyeong Kim; Himadri Sharma; Moon Il Kim; Hyon Lee; Minju Kim; Nayoung Ryoo; Min Ju Kang; Jung-Min Pyun; Young Ho Park; Jisun Ryu; Hyun Jung Oh; Hyun-Sik Yang; Hang-Rai Kim; Geon Ha Kim; Sangwon Han; YoungSoon Yang; Young Chul Youn; Charlotte Teunissen; Henrik Zetterberg; Philip Scheltens; Seong Soo A An; Young-Bum Kim; SangYun Kim; Alzheimer's Disease All Markers (ADAM) Research Group Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, predominantly affecting the aging population. Early detection through biomarkers is essential for early intervention. Recent sub-classification of AD through extensive cerebrospinal fluid (CSF) proteomic analyses revealed distinct characteristics of each subtype, necessitating tailored therapeutic strategies. While CSF proteomics has identified potential biomarkers, the need for non-invasive and cost-effective substitutions highlights the importance of blood-based biomarkers (BBMs). This review is a comprehensive review that categorizes potential BBMs based on neuronal hyperplasticity (subtype 1), underlining their role in refining subtype classification and enabling precision medicine. Early AD is often marked by cortical and hippocampal hyperactivity, followed by hypoactivity during later stages of neurodegeneration. While the exact mechanisms remain unclear, factors like Ca2+, glutamate, amyloid beta, tau, genetic factors, and impaired glial function play a role. Advancements in blood-based diagnostics would improve detection, individual treatment strategies, and evaluation of therapeutic response, eventually reducing the burden of AD on health-care systems. HIGHLIGHTS: Alzheimer's disease (AD; subtype 1) exhibits neuronal hyperplasticity, mild cortical atrophy, and moderate microglial activation. The neuronal hyperplasticity subtype of AD is characterized by an upregulation of synaptic and plasticity-related proteins, distinguishing it from other AD subtypes. Identifying biomarkers specific to neuronal hyperplasticity would enable real-time monitoring of therapeutic responses, allowing for individualized therapy as opposed to a "one-size-fits-all" strategy. The treatments based on neuronal hyperactivity reduction, restoration of synaptic plasticity, and anti-inflammation/metabolic dysfunction would be useful in this AD subtype. Blood-based biomarkers offer a cost-effective and accessible alternative to cerebrospinal fluid and neuroimaging methods. Tue, 31 Dec 2024 15:00:00 GMT http://schca-ir.schmc.ac.kr/handle/2022.oak/4920 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4841 Title: Efficacy Comparison of Multiplanar Deformity Reducer System and Direct Vertebral Rotation in Adolescent Idiopathic Scoliosis Corrective Surgery All Author(s): Sungjae An; Seung-Jae Hyun; Jae-Min Ahn; Byoung-Joo Park; Seong-Hyun Wui; Ki-Jeong Kim Abstract: Objective: This study aims to evaluate the efficacy of the multiplanar deformity reducer (MDR) and direct vertebral rotation (DVR) techniques in surgically treating adolescent idiopathic scoliosis (AIS), focusing on surgical and radiographic outcomes. Methods: A retrospective analysis was conducted on AIS patients who underwent surgery between December 2017 and August 2019, comparing the outcomes of those treated with MDR system and DVR technique. Data on demographics and surgical characteristics were collected, while radiographic parameters were measured manually by three spine surgeons and by EOS 3D analysis (EOS imaging, Paris, France). Results: Nine patients were surgically corrected with the MDR system and 13 with DVR, who were predominantly females with an average age in their late teens. Despite more fusion levels in the MDR group (12.3±1.0) compared to the DVR group (10.0±3.2), operation time, blood loss, overall radiographic correction, and patient-reported outcome was comparable. Moreover, only the interrater reliability for manual apical vertebral rotation measurements was below good, which necessitates the use of EOS 3D analysis. Conclusion: The MDR technique is effective and safe for AIS surgery, offering comparable corrective efficacy to the DVR technique. Furthermore, EOS 3D imaging was more reliable for assessing rotational deformities, which incorporates pelvic position. Tue, 31 Dec 2024 15:00:00 GMT http://schca-ir.schmc.ac.kr/handle/2022.oak/4841 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4828 Title: A Comprehensive Analysis of Stent during Stent Assisted Coil Embolization for Cerebral Aneurysms: A 17-Year Institutional Study All Author(s): Kihun Kim; Jong-Hyun Park; Gi Yong Yun; Jae-Min Ahn; Hyuk-Jin Oh; Jai-Joon Shim; Seok Mann Yoon Abstract: Aim: To compare the outcomes and complications of stent-assisted coil (SAC) embolization for the treatment of cerebral aneurysms according to stent type. Material and methods: Since January 2006, a total of 1293 patients have been added to our institutional aneurysm database. We excluded cases with subarachnoid hemorrhage, those not classified as Raymond Roy Class 1, and those in which flow diverters were used. Cases involving the use of overlapping stents, Y-stenting, or multiple stents were also excluded. We recorded demographic information, aneurysm characteristics, and procedural details for all patients. Patients who did not undergo diffusionweighted magnetic resonance imaging (MRI) within 1 day postoperatively or follow-up angiography within 6 months postoperatively were excluded. Results: In total, 188 patients were included in the analysis (129 females; mean age, 58 years) who were treated for aneurysms of different sizes. Regrowth occurred in 21 patients, with the rate varying according to the stent type. In particular, the lower profile stent group had a lower regrowth rate compared to the nitinol laser stent group. The rate of postoperative infarction on diffusionweighted MRI within 1 day postoperatively varied among stent types. Conclusion: None of the stent types demonstrated clear superiority for SAC embolization, indicating that stent selection should be based on surgeon preference. Despite the low regrowth rate, careful stent selection is essential, particularly for patients at high risk of ischemic stroke or regrowth. These findings provide valuable insights for optimizing the treatment of cerebral aneurysms using SAC embolization. Tue, 31 Dec 2024 15:00:00 GMT http://schca-ir.schmc.ac.kr/handle/2022.oak/4828 2024-12-31T15:00:00Z