http://schca-ir.schmc.ac.kr/handle/2022.oak/122 2026-10-22T23:02:37Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4987 Title: Liver-specific propanoate metabolism-derived 2-ethylhexanol as a novel biomarker for precise diagnosis and prognosis of hepatocellular carcinoma All Author(s): Dongyong Lee; Jinhee Mun; Jihyun Lee; Chan Jang; Geumjong Song; Jonghyuk Yun; Kwangseock Kim; Taewan Kim; Seob Jeon; Jinmyoung Joo Abstract: Alterations in propanoate metabolism are increasingly recognized as significant biomarkers for various liver disorders, notably hepatocellular carcinoma (HCC). To enhance diagnostic specificity for HCC, we conducted integrated binary omics and targeted metabolomics analyses, identifying liver-specific propanoate metabolism (LPM) gene signatures and associated metabolites. Leveraging data from 40 tissues and 81 cell subclasses, hepatocytes showed the highest metabolic specificity. Clinical validation using the TCGA-LIHC cohort highlighted LPM genes, notably ALDH2 and ABAT, as robust prognostic markers significantly associated with poor survival outcomes. Serum metabolomic profiling of 273 patients demonstrated that elevated toluene and xylene isomers and significantly reduced 2-ethylhexanol distinctly characterize HCC, distinguishing it from liver cirrhosis, hepatitis, and other cancers. These findings emphasize the potential of LPM-based metabolic profiling as a precise diagnostic and prognostic tool, with potential implications in targeted therapeutic development for HCC. 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4969 Title: Is the double-ligation method safe and effective in laparoscopic paediatric inguinal hernia repair? A retrospective cohort study All Author(s): Jong Hyuk Yun; Myoung Won Son; Geum Jong Song; Moon-Soo Lee Abstract: Introduction: Laparoscopic paediatric hernia repair has since been performed more frequently. Recently, a double-ligation method was introduced to prevent recurrence in laparoscopic surgery. The objective of our study was to compare the postoperative outcomes of patients who underwent double and single ligations. Patients and methods: We performed a retrospective review of patients with inguinal hernia who underwent laparoscopic paediatric inguinal hernia repair from 2014 to 2018 at our institution. Patients were divided into two groups and underwent single ligation and double ligation. Results: Three hundred and six patients (single-ligation group: 142 and double-ligation group: 164) were included. Four patients experienced recurrence, and the recurrence rate was 1.29%. The recurrence rate was significantly higher in the single-ligation group. There were no statistically significant differences in the postoperative complications between the two groups. Conclusion: Double-ligation method in laparoscopic paediatric hernia repair was relatively safe and helpful. 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4959 Title: The efficacy of a symptom management platform among gastric cancer survivors: a study protocol for a randomized controlled trial All Author(s): Jeong Ho Song; Joongyub Lee; Jae Seok Min; Hyungkook Yang; Jong Hyuk Yun; Hayemin Lee; Eun Young Kim; Su Mi Kim; Sol Lee; Ki Bum Park; Geum Jong Song; Ji Ho Park; Bang Wool Eom; Hoon Hur; Sang Ho Jeong Abstract: Background: Patients who undergo gastrectomy for gastric cancer experience gastrointestinal symptoms, psychological responses, and social problems. These factors reduce a patient's quality of life (QoL) after surgery. A web-based platform (Wecare®) has been developed to address distress and provide solutions. This study aimed to evaluate whether Wecare® improved the QoL of patients who underwent gastrectomy. Methods: A total of 88 patients who undergo gastrectomy for gastric cancer will be randomly allocated to either the "Wecare®" group or the control group at a 1:1 ratio. After using the "Wecare®" platform for the first 22 patients and making modifications, the next 66 patients will be randomized equally. The primary outcome of this trial is the QoL among gastric cancer survivors (KOQUSS-40). The values of weight change, nutritional index change, KOQUSS-40 questionnaire compliance, self-efficacy, physical activity change, and satisfaction will be compared between the two groups as secondary outcomes. The investigator will follow-up with the patients at 1, 3, and 6 months after surgery at the outpatient clinic. Discussion: This is the first randomized controlled trial to analyze the usefulness of a symptom management platform (Wecare®) among gastric cancer survivors. This study aimed to verify the efficacy of web-based platforms in relieving discomfort after gastric cancer surgery. Future large-scale clinical trials are planned. 2024-12-31T15:00:00Z http://schca-ir.schmc.ac.kr/handle/2022.oak/4913 Title: Patients' Preferences for Gastric Cancer Treatment: A Cross-Sectional Study on Decision-Making in Multidisciplinary Treatment Strategies All Author(s): Tae-Han Kim; In-Ho Kim; Seung Joo Kang; Geum Jong Song; Mi Ran Jung; Hye Sook Han; Su Youn Nam; Seong-Ho Kong Abstract: Purpose: Decisions regarding gastric cancer treatment affect patient outcomes and quality of life (QOL); nonetheless, factors influencing patient preferences remain unclear. This study investigated the preferences for the extent of gastrectomy, minimally invasive surgery, and adjuvant therapy while identifying the key determinants. Materials and methods: A cross-sectional survey of 240 respondents, including patients with gastric cancer and the general population, assessed their preferences for the extent of gastrectomy, surgical modality, adjuvant therapy, palliative systemic therapy, and endoscopic therapy. Correlations between demographic variables and treatment choices were statistically analyzed. Results: Patients prioritized expert recommendations for determining the extent of gastrectomy for proximal gastric cancer and selecting the surgical modality, with recurrence risk and surgical complications being the primary considerations. In terms of adjuvant therapy, a 12-month oral regimen was preferred over a 6-month oral plus injection regimen, with survival benefit being the most valued factor. Conversely, QOL was a primary concern in palliative therapy. With respect to incomplete endoscopic submucosal dissection, electrocauterization was the preferred approach, followed by surgical resection; local recurrence risk was assigned with the highest priority, followed by concerns regarding lymph node metastasis. Men and individuals living alone had a lower risk of recurrence and lymph node metastasis. Patients undergoing gastric cancer treatment preferred shorter procedures, whereas medical personnel emphasized surgical safety and efficiency. Conclusions: Demographic and clinical factors significantly influence patient preferences. Understanding these preferences is essential for shared decision-making and personalized oncological care. 2024-12-31T15:00:00Z